| | | 人才隊(duì)伍 |
一,、團(tuán)隊(duì)簡介
團(tuán)隊(duì)目前由6人組成,，其中教授3人、副教授2人,、中級1人,、博士3人、在讀博士1人,、碩士2人,；參與本團(tuán)隊(duì)研究工作的在讀研究生5人,。在團(tuán)隊(duì)人員組成中，享受湖北省政府特殊津貼專家2人,、中國化工學(xué)會(huì)精細(xì)化工專業(yè)委員會(huì)委員1人,，核心期刊、中國化工學(xué)會(huì)精細(xì)化工專業(yè)委員會(huì)會(huì)刊《精細(xì)化工》雜志編委1人,。
二,、主要研究內(nèi)容及成果
近年來，本團(tuán)隊(duì)主要致力于天然產(chǎn)物及生物活性物質(zhì)研究,。主要有以下幾個(gè)方面：特色植物厚樸中天然活性物質(zhì)和厚樸酚的分離,、提取及抗植物病菌、抗動(dòng)脈粥樣硬化作用機(jī)理研究,；天然產(chǎn)物衍生物化學(xué)合成及其生物活性研究,，包括具有抗植物真菌病、促進(jìn)細(xì)胞分裂等活性的化合物,；環(huán)境微生物的抗腫瘤活性,；武陵地區(qū)特色芳香天然產(chǎn)物香氣成分及其合成。
本團(tuán)隊(duì)共承擔(dān)科研項(xiàng)目20余項(xiàng),，其中主持國家自然科學(xué)基金項(xiàng)目6項(xiàng),、主持和參與湖北省高等學(xué)校優(yōu)秀中青年科技創(chuàng)新團(tuán)隊(duì)計(jì)劃項(xiàng)目2項(xiàng)、主持湖北省自然科學(xué)基金項(xiàng)目多項(xiàng),。2009年以來，發(fā)表論文100余篇,，17篇被SCI,、EI收錄；本團(tuán)隊(duì)出版著作2部,；獲得授權(quán)發(fā)明專利4項(xiàng),。
主要科研項(xiàng)目
1．紫油厚樸藥材道地性形成的機(jī)制研究（81460573）．國家自然科學(xué)基金地區(qū)科學(xué)基金項(xiàng)目
2. 納米金屬/合金的原位形貌調(diào)控制備及酚類污染物電化學(xué)傳感（21361009）. 國家自然科學(xué)基金
3．基于抗壞血酸的Maillard反應(yīng)動(dòng)力學(xué)研究（31360408）．國家自然科學(xué)基金地區(qū)科學(xué)基金項(xiàng)目
4. EGFR/ErbB2雙靶點(diǎn)抑制劑的設(shè)計(jì)、合成及生物活性研究（21262012）. 國家自然科學(xué)基金地區(qū)科學(xué)基金項(xiàng)目
5. 基于表面增強(qiáng)三維納米陣列環(huán)境激素電化學(xué)傳感器研究（21175033）. 國家自然科學(xué)基金
6．基于抗壞血酸的Maillard反應(yīng)形成肉香分子的機(jī)理及其產(chǎn)物的抗氧化活性研究（20876036）．國家自然科學(xué)基金面上項(xiàng)目.
7.武陵地區(qū)特色芳香天然產(chǎn)物的香氣成分及其合成（T200707）．湖北省高等學(xué)校優(yōu)秀中青年科技創(chuàng)新團(tuán)隊(duì)計(jì)劃項(xiàng)目.
8.內(nèi)分泌干擾物納米電化學(xué)傳感及快速檢測新方法研究（2009CDB024）. 湖北省自然科學(xué)基金
9.新型細(xì)胞分裂素類物質(zhì)的設(shè)計(jì),、合成及構(gòu)效關(guān)系（2007ABA001）,，湖北省自然科學(xué)基金項(xiàng)目
10.重金屬污染污泥中真菌的抗腫瘤活性產(chǎn)物研究（20110500190）.中國博士后科學(xué)基金第五十批面上資助項(xiàng)目
11.污泥中廢棄微生物的抗腫瘤活性產(chǎn)物研究（2013M530486）.中國博士后科學(xué)基金第五十三批面上資助項(xiàng)目
12.和厚樸酚抗動(dòng)脈粥樣硬化作用. 國家民委資助項(xiàng)目. 2008
13. 和厚樸酚抗動(dòng)脈粥樣硬化作用及其機(jī)理的研究. 湖北省自然科學(xué)基金. 2008
主要科研論文：
1. Determination of 4-aminophenol using a glassy carbon electrode modified with a three-dimensionally ordered macroporous film of polycysteine.Microchim Acta, 2015
2. One-step solvent exfoliation of graphite to produce a highly-sensitive electrochemical sensor for tartrazine. Sensors and Actuators B: Chemical, 2014
3. A novel nanoporous film electrode based on electrochemical polymerization of ionic liquid and its application in sensitive determination of magnolol. Talanta, 2014, 4. A nanostructured poly(2-mercapto-4-amino-5-cyano-6-phenylpyrimidine) film for sensitive determination of methyl parathion. Nanoscience and Nanotechnology Letters, 2014
5. Facile synthesis and antitumor activity of novel 2-trifluoromethylthieno[2,3- d]pyrimidine derivatives. Chinese Chemical Letters, 2014
6. Synthesis and biological activity of new fluorinated thieno[2,3-d]pyrimidinyl hydrazone derivatives. Letters in Organic Chemistry, 2014
7. Preparation of three-dimensionally ordered macroporous polycysteine film and application in sensitive detection of 4-chloropheno.Electrochimica Acta, 2014
8. Synthesis, crystal structure, and antitumor activity of 1-(4-methoxybenzyli- dene)-2-(1-phenyl-6-trifluoromethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine monohydrate. Chinese Journal of Structural Chemistry, 2014
9. Enhanced oxidation and detection of methyl parathion using an acetylene black nanoparticle–dihexadecyl hydrogen phosphate composite film.Analytical Methods，2014
10. Mechanistic studies on the formation of pyrazines by Maillard reaction between L-ascorbic acid and L-glutamic acid. LWT - Food Science and Technology, 2013
11. Synthesis, crystal structure, and biological activity of 4-chlorobenzaldehyde (2-trifluoromethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)- hydrazone monohydrate. Chinese Journal of Structural Chemistry, 2013
12. Mechanism of Formation of Sulfur Aroma Compounds from L-Ascorbic Acid and L-Cysteine during the Maillard Reaction. Food Chemistry, 2012
13. Influence of the pH on the formation of pyrazine compounds by the Maillard reaction of L-ascorbic acid with acidic, basic and neutral amino acids. Asia-Pacific Journal of Chemical Engineering, 2012.
14. Volatiles from the Maillard reaction of L-ascorbic acid with L-glutamic acid/L-aspartic acid at different reaction times and temperatures. Asia-Pacific Journal of Chemical Engineering, 2012
15. Facile synthesis of novel fluorinated thieno[2,3-d]pyrimidine derivatives containing 1,3,4-thiadiazole. Chinese Chemical Letters, 2012
16. Electrochemical determination of p-cresol using mesoporous TiO2-modified carbon paste electrode .Russian Journal of electrochemistry,2011
17. Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimi- dine derivatives containing 1,3,4-thiadiazole as potentialantitumor agents. Chinese Chemical Letters, 2011
18. Biosynthesis of di-n-butyl phthalate from filamentous fungi. Nature communication. (NCOMMA-15-02155).
19. Aroma compounds generated from thermal reaction of L-ascorbic acid with L-cysteine. Food Chemistry, 2010
20. The effect of pH on the formation of aroma compounds produced by heating a model system containing l-ascorbic acid with l-threonine/ l-serine. Food Chemistry, 2010
21. Chemical composition of the essential oil of the roots of Actinidia chinensis from China. Chemistry of Natural Compounds, 2009
22. Volatiles from the Maillard Reaction of l-Ascorbic Acid and l-Alanine at Different pHs. Food Science and Biotechnology, 2009
23. 特殊生境真菌的分離培養(yǎng)及其抗腫瘤活性篩選. 國際藥學(xué)研究雜志,，2008
24. 細(xì)胞壁通透性調(diào)控在真菌菌株選育中的應(yīng)用. 中國海洋大學(xué)學(xué)報(bào)（自然科學(xué)版）,，2010
25. 兩株無抗腫瘤活性放線菌野生株的抗生素抗性突變株及其抗腫瘤活性篩選. 中國海洋大學(xué)學(xué)報(bào)（自然科學(xué)版），2010
26. 超聲輔助提取厚樸葉中厚樸酚及和厚樸酚的研究. 時(shí)珍國藥雜志, 2008
27. 微波輔助提取厚樸中厚樸酚及和厚樸酚的研究. 中華中醫(yī)藥雜志, 2008
28. 加味藿香正氣丸中厚樸酚與和厚樸酚提取及含量測定. 中華中醫(yī)藥雜志, 2008
29. HPLC法測定快速溶劑萃取開胸順氣丸中厚樸酚與和厚樸酚. 中草藥, 2008
授權(quán)發(fā)明專利
1. 余愛農(nóng). 豆豉香麻辣調(diào)味油及其生產(chǎn)方法．專利號(hào)：ZL 02 1 43664.9.
2. 余愛農(nóng). 箬葉多糖的提取方法．專利號(hào)：ZL 03 1 42883.5.
3. 田從魁. 二酮哌嗪類化合物,、其組合物,、其制備方法和用途. 專利號(hào)：ZL 2010 1 0560936.1.
4. 田從魁. 真菌次級代謝功能改造相關(guān)實(shí)驗(yàn)技術(shù)及其用途. 專利號(hào)：ZL 2010 1 0000035.7.